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Introduction:
The relation between sequence, structure and function of
proteins
Sequence determines structure
Homologous proteins are of the same evolutionary origin. Despite the differences which have been accumulated in their sequences, the structure and function of these proteins can be remarkably conserved.Different sequences can result in similar structures
We can learn about the important features which determine structure and function by comparing the sequences and structures of homologs.
| In this exercise, we will look at the globin family in order to understand how
the structure and function of the protein have been conserved throughout
evolution (Lesk & Chothia). We will use sequence alignment and structure alignment to compare between the different proteins and examine the features that determine structural and functional conservation. |
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