The next step in the diagnostic and management process is visualization of the large intestine.  This is done using hygroscopic material that will in addition to showing the large intestine liquefy the meconium in the distal ileum and thus treat the problem without an operation.  In previous years, Gastrographin was used. This high osmolar contrast solution has been replaced by isosmolar water-soluble contrast agents, which do not produce the severe fluid electrolyte imbalance seen following Gastrographin.  Therapy with Gastrographin Enemas was first described by Dr. Helen Noblett, an Australian Pediatric Surgeon in 1969.  In excess of 62% of patients with meconium ileus can be successfully treated with an enema. 

 

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